Chaperone Code & CSSI Meeting 2023
The 2nd International Symposium on the Chaperone Code
October 26-28, 2023
Hilton Alexandria Old Town, VA, USA
Organizers: Mark Woodford, Dimitra Bourboulia, Mehdi Mollapour
Molecular chaperones have been extensively studied for the last 50 years; they are highly conserved and are essential for many cellular processes. Research has primarily focused on how chaperone function is regulated via transcription, expression of highly related paralogs and the suite of co-chaperone binding partners.
Despite this, we still know very little about the post-translational modification (PTM) of chaperone proteins and how these modifications may affect their cellular function. Powerful technologies such as affinity purification of proteins coupled with tandem mass spectrometry (AP-MS/MS) have uncovered a substantial number of modified sites on both Hsp70 and Hsp90. These PTMs can be added and removed rapidly, allowing fine-tuning chaperone function when required. The large number of detected modifications such as phosphorylation, ubiquitination, SUMOylation and acetylation) suggest a “chaperone code” similar in nature to the combinatory PTM code that exists on histones.
We consider the chaperone code as the ultimate frontier in chaperone research. The understanding of the reciprocal interplay between chaperones and key signal transductions system will lead to an unprecedented ability to manipulate chaperone function for experimental and translational purposes. This meeting unites like-minded researchers to collaborate in cracking this monumental biological conundrum.
12th International Symposium on Heat Shock Proteins in Biology and Medicine Program
Welcome address by the organizers
Keynote lecture: Matthias Mayer
Session 1: HSP transcription and HSF1 (Chair: Stuart Calderwood)
Valerie Lallemand Mezger
Session 2: HSP inhibitors as therapeutics, Hsp90 inhibitors and beyond (Chair: Len
Session 3: Chaperones in the extracellular and transcellular stress response
Patricija van Oosten-Hawle
Shawn Xiang Wang
Session 4: The HSR in context (Chair: Betsy Repasky)
Session 5: Chaperone networks, co-chaperones in the stress response and as targets
Session 6: Protein quality control, autophagy, protein folding disorders, aging. Large,
middle and small HSPs, HSF1
Wrap-up & Lunch